多重耐药性高毒力：一种不断演变的超级细菌
Multidrug-resistant hypervirulent : an evolving superbug.
作者信息
Zheng Yu, Zhu Xiaojue, Ding Chao, Chu Weiqiang, Pang Xiaoxiao, Zhang Ruxia, Ma Jiucheng, Xu Guoxin
机构信息
Department of Clinical Laboratory, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, China.
Department of Burns and Plastic Surgery, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, China.
出版信息
Future Microbiol. 2025 Apr;20(6):499-511. doi: 10.1080/17460913.2025.2482478. Epub 2025 Mar 26.
Multidrug-resistant hypervirulent (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue to emerge, shattering the perception that hypervirulent (hvKP) strains are antibiotic sensitive. Patients infected with MDR-hvKP strains have been reported in Asia, particularly China. Although hvKP can acquire drug resistance genes, MDR-hvKP seems to be more easily transformed from classical (cKP), which has a strong gene uptake ability. To better understand the biology of MDR-hvKP, this review discusses the virulence factors, resistance mechanisms, formation pathways, and identification of MDR-hvKP. Given their destructive and transmissible potential, continued surveillance of these organisms and enhanced control measures should be prioritized.
多重耐药高毒力（MDR-hvKP）将高致病性与多重耐药性结合在一起，成为一种新的超级细菌。MDR-hvKP的报道不断出现，打破了高毒力（hvKP）菌株对抗生素敏感的认知。亚洲，尤其是中国，已有感染MDR-hvKP菌株的患者报道。虽然hvKP可获得耐药基因，但MDR-hvKP似乎更容易从具有强大基因摄取能力的经典（cKP）菌株转化而来。为了更好地了解MDR-hvKP的生物学特性，本综述讨论了MDR-hvKP的毒力因子、耐药机制、形成途径及鉴定方法。鉴于其具有的破坏和传播潜力，应优先持续监测这些病原体并加强控制措施。
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