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转化研究在眼部弓形虫病研究中的重要性:来自2024年第17届国际弓形虫病大会的见解

The importance of translational research in the study of ocular toxoplasmosis: insights from the 17th International Congress on Toxoplasmosis 2024.

作者信息

de-la-Torre Alejandra, Mejía-Salgado Germán, Schares Gereon

机构信息

Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 110321, Colombia.

Ophthalmology Interest Group Universidad del Rosario (OIG UR), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogota 110321, Colombia.

出版信息

FEMS Microbes. 2025 Mar 3;6:xtaf003. doi: 10.1093/femsmc/xtaf003. eCollection 2025.

Abstract

Toxoplasmosis is a parasitic infection with significant implications for human health, particularly in its ocular form, which can lead to severe visual impairment. While both basic and clinical research have made considerable strides in understanding the biology and treatment of this parasite, challenges remain. Recent advancements in diagnostics, mainly through multimodal imaging, have improved the identification of active disease and predicting outcomes. Experimental therapies are also emerging, offering new hope for more effective treatments. However, the most critical insight from recent research, particularly emphasized at the 17th International Congress on Toxoplasmosis, is the necessity of a collaborative approach. Integrating basic and clinical research is essential for translating molecular and pathophysiological findings into effective clinical practices. This synergy is crucial for advancing treatment strategies and improving patient outcomes in ocular toxoplasmosis.

摘要

弓形虫病是一种对人类健康有重大影响的寄生虫感染,尤其是眼部形式的弓形虫病,可导致严重视力损害。尽管基础研究和临床研究在了解这种寄生虫的生物学特性和治疗方法方面都取得了长足进展,但挑战依然存在。诊断方面的最新进展,主要是通过多模态成像,改善了对活动性疾病的识别和预后预测。实验性疗法也不断涌现,为更有效的治疗带来了新希望。然而,近期研究中最关键的见解,尤其是在第17届国际弓形虫病大会上特别强调的,是采取协作方法的必要性。整合基础研究和临床研究对于将分子和病理生理学研究结果转化为有效的临床实践至关重要。这种协同作用对于推进眼部弓形虫病的治疗策略和改善患者预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca3/11951098/24d813a2d69e/xtaf003fig1.jpg

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