新型白细胞介素-8基因突变对沙特阿拉伯卵巢癌患者白细胞介素-8蛋白结构及稳定性的影响
Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia.
作者信息
Haque Absarul, Baig Ghazanfar Ali, Alshawli Abdulelah Saleh, Wali Sait Khalid Hussain, Mohammed Ali Hani S H, Hussain Sait Hesham Khalid, Bibi Fehmida, Pushparaj Peter Natesan, Rasool Mahmood, Naseer Muhammad Imran
机构信息
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Bioinformation. 2024 Nov 30;20(11):1671-1677. doi: 10.6026/9732063002001671. eCollection 2024.
Despite advancements in therapeutics, early diagnosis of ovarian cancer (OC) remains a challenge due to its asymptomatic progression and it is often diagnosed at an advanced stage. Interleukin-8 (IL-8), a pro-inflammatory chemokine with angiogenic activity, plays a pivotal role in inflammation and carcinogenesis. Therefore, it is of interest to investigate the association between IL-8 polymorphisms and OC risk. A novel non-synonymous SNP (nsSNP, c.193G>A; p.Glu65Leu) was identified in exon 2 of the IL-8 gene in 5 patients, 3 with stage III and 2 with stage II tumor. Structural analysis suggested that the p.Glu65Leu mutation alters the IL-8 protein conformation showing functional impairment. Thus, data shows that IL-8 c.193 G >A (Glu65Leu) polymorphism may contribute to tumor susceptibility. However, further studies are warranted to understand the role of IL-8 polymorphism in OC.
尽管治疗方法有所进步，但由于卵巢癌（OC）无症状进展，其早期诊断仍然是一项挑战，而且它往往在晚期才被诊断出来。白细胞介素-8（IL-8）是一种具有血管生成活性的促炎趋化因子，在炎症和致癌过程中起关键作用。因此，研究IL-8基因多态性与OC风险之间的关联很有意义。在5例患者的IL-8基因外显子2中鉴定出一种新的非同义单核苷酸多态性（nsSNP，c.193G>A；p.Glu65Leu），其中3例为III期肿瘤，2例为II期肿瘤。结构分析表明，p.Glu65Leu突变改变了IL-8蛋白构象，显示出功能受损。因此，数据表明IL-8 c.193 G>A（Glu65Leu）多态性可能与肿瘤易感性有关。然而，需要进一步研究以了解IL-8多态性在OC中的作用。
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