工作年龄成年人的睡眠障碍、轮班工作与表观遗传衰老：芬兰青年研究的结果

Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study.

作者信息

Autio Ida, Saarinen Aino, Marttila Saara, Raitoharju Emma, Mishra Pashupati P, Mononen Nina, Kähönen Mika, Keltikangas-Järvinen Liisa, Raitakari Olli, Lehtimäki Terho

机构信息

Department of Psychology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.

Molecular Epidemiology, Faculty of Medicine and Health Technology, Cardiovascular Research Center Tampere, Tampere University, Tampere, Finland.

出版信息

Clin Epigenetics. 2025 Apr 2;17(1):55. doi: 10.1186/s13148-025-01860-w.

DOI:10.1186/s13148-025-01860-w

PMID:40176161

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11966881/

Abstract

BACKGROUND

Sleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epigenetic ageing is limited. We investigated (1) whether symptoms of insomnia, obstructive sleep apnoea, sleep deprivation, and circadian rhythm lateness are associated with epigenetic ageing, and (2) whether years spent in shift work moderates these associations.

METHODS

We used the population-based Young Finns data (n = 1618). Epigenetic clocks such as AgeDev, AgeDev, AgeDev, AgeDev, and DunedinPACE were utilized to measure epigenetic ageing. Sleep was evaluated using various validated self-report questionnaires. Covariates included sex, array type, smoking status, health behaviours, socioeconomic factors, and cardiovascular health factors.

RESULTS

Among the various sleep measures, obstructive sleep apnoea symptoms were most consistently linked to accelerated epigenetic ageing, as measured by AgeDev and DunedinPACE. Insomnia, sleep deprivation, and years spent in shift work were not associated with epigenetic ageing after adjusting for health-related or socioeconomic covariates. Additionally, we found interactions between years spent in shift work and sleep disturbances when accounting for epigenetic ageing. Among those with little to no history of shift work, both insomnia and sleep deprivation were associated with more accelerated epigenetic ageing in AgeDev when compared to long-term shift workers. However, the pace of epigenetic ageing (measured with DunedinPACE) appears to be higher in those with both sleep deprivation and longer history of shift work.

CONCLUSIONS

Among various sleep measures, symptoms of obstructive sleep apnoea appear to be most consistently associated with accelerated epigenetic ageing even after adjusting for various health-related and socioeconomic factors. Shift work seems to have a crucial role in the relationship between sleep disturbances and epigenetic ageing in working-age adults.

摘要

背景

睡眠障碍已知会对健康产生不利影响，但关于睡眠障碍对表观遗传衰老影响的知识有限。我们调查了：（1）失眠、阻塞性睡眠呼吸暂停、睡眠剥夺和昼夜节律延迟的症状是否与表观遗传衰老相关；（2）轮班工作的年限是否会调节这些关联。

方法

我们使用了基于人群的年轻芬兰人数据（n = 1618）。利用诸如AgeDev、AgeDev、AgeDev、AgeDev和达尼丁PACE等表观遗传时钟来测量表观遗传衰老。使用各种经过验证的自我报告问卷对睡眠进行评估。协变量包括性别、芯片类型、吸烟状况、健康行为、社会经济因素和心血管健康因素。

结果

在各种睡眠指标中，阻塞性睡眠呼吸暂停症状与通过AgeDev和达尼丁PACE测量的表观遗传衰老加速最为一致相关。在调整了与健康相关或社会经济协变量后，失眠、睡眠剥夺和轮班工作的年限与表观遗传衰老无关。此外，在考虑表观遗传衰老时，我们发现轮班工作的年限与睡眠障碍之间存在相互作用。与长期轮班工作者相比，在几乎没有或没有轮班工作史的人群中，失眠和睡眠剥夺在AgeDev中均与表观遗传衰老加速相关。然而，在同时存在睡眠剥夺和较长轮班工作史的人群中，表观遗传衰老的速度（用达尼丁PACE测量）似乎更高。