肿瘤学中的下一代测序——靶向治疗及新兴应用的指南
Next-Generation Sequencing in Oncology-A Guiding Compass for Targeted Therapy and Emerging Applications.
作者信息
Galeș Laurenția Nicoleta, Păun Mihai-Andrei, Butnariu Ioana, Simion Laurentiu, Manolescu Loredana Sabina Cornelia, Trifănescu Oana Gabriela, Anghel Rodica Maricela
机构信息
"Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Medical Oncology II, "Prof. Dr. Al. Trestioreanu" Institute of Oncology, 022328 Bucharest, Romania.
出版信息
Int J Mol Sci. 2025 Mar 28;26(7):3123. doi: 10.3390/ijms26073123.
Multigene sequencing technologies provide a foundation for targeted therapy and precision oncology by identifying actionable alterations and enabling the development of treatments that substantially improve clinical outcomes. This review emphasizes the importance of having a molecular compass guiding treatment decision-making through the multitude of alterations and genetic mutations, showcasing why NGS plays a pivotal role in modern oncology.
多基因测序技术通过识别可操作的改变并推动开发能显著改善临床结果的治疗方法，为靶向治疗和精准肿瘤学奠定了基础。本综述强调了拥有一个分子指南以指导通过众多改变和基因突变进行治疗决策的重要性，展示了为什么二代测序（NGS）在现代肿瘤学中发挥着关键作用。
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