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饲料中的霉菌毒素:危害、毒理学及基于植物提取物的补救措施

Mycotoxins in Feed: Hazards, Toxicology, and Plant Extract-Based Remedies.

作者信息

Zhang Xiangnan, Chen Jiashun, Ma Xiaokang, Tang Xiongzhuo, Tan Bie, Liao Peng, Yao Kang, Jiang Qian

机构信息

Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.

Yuelushan Laboratory, Changsha 410128, China.

出版信息

Metabolites. 2025 Mar 24;15(4):219. doi: 10.3390/metabo15040219.

Abstract

Mycotoxins, which are secondary metabolites produced by fungi, are prevalent in animal feed and pose a serious risk to the healthy growth of livestock and poultry. This review aims to conclude current knowledge on the detrimental effects of mycotoxins on animal health and to demonstrate the potential of plant extracts as a means to counteract mycotoxin toxicity in feed. A systematic review of the literature was conducted to identify studies on the impact of mycotoxins on livestock and poultry health, as well as research into the use of plant extracts as feed additives to mitigate mycotoxin effects. Studies were selected based on their relevance to the topic, and data were extracted regarding the mechanisms of action and the efficacy of plant extracts. Excessive mycotoxins in feed can lead to reduced appetite, impaired digestion, and general health issues in animals, resulting in decreased food intake, slowed weight gain, and instances of acute poisoning. Plant extracts with antioxidant, anti-inflammatory, and anti-mutagenic properties have shown the potential to improve production efficiency and reduce the toxic effects of mycotoxins. This comprehensive review not only consolidates the well-documented adverse effects of mycotoxins on animal health but also introduces a novel perspective by highlighting the potential of plant extracts as a promising and natural solution to counteract mycotoxin toxicity.

摘要

霉菌毒素是由真菌产生的次生代谢产物,在动物饲料中普遍存在,对畜禽的健康生长构成严重威胁。本综述旨在总结目前关于霉菌毒素对动物健康有害影响的知识,并展示植物提取物作为对抗饲料中霉菌毒素毒性手段的潜力。对文献进行了系统综述,以确定有关霉菌毒素对畜禽健康影响的研究,以及关于使用植物提取物作为饲料添加剂减轻霉菌毒素影响的研究。根据研究与主题的相关性进行选择,并提取有关植物提取物作用机制和功效的数据。饲料中过量的霉菌毒素会导致动物食欲下降、消化受损和一般健康问题,从而导致采食量减少、体重增加缓慢和急性中毒情况。具有抗氧化、抗炎和抗诱变特性的植物提取物已显示出提高生产效率和降低霉菌毒素毒性作用的潜力。这一全面综述不仅巩固了关于霉菌毒素对动物健康的充分记录的不利影响,还通过强调植物提取物作为对抗霉菌毒素毒性的一种有前景的天然解决方案的潜力引入了一个新的视角。

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