N6-甲基腺苷与非编码RNA在多发性骨髓瘤中的研究进展
Research progress on N6-methyladenosine and non-coding RNA in multiple myeloma.
作者信息
Sun Xiaoqi, Zhou Yongming, Zhu Wenwei, Chen Hailin
机构信息
Department of Hematology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
出版信息
Discov Oncol. 2025 Apr 25;16(1):615. doi: 10.1007/s12672-025-02386-6.
N6-methyladenosine (m6A) and non-coding RNA (ncRNA) play important roles in the occurrence, development, and prognosis of multiple myeloma (MM). They not only affect stemness, growth, and apoptosis of MM cells but also intervene in MM proliferation, migration, invasion, and even drug resistance. It is also a prognostic factor for poor MM survival. Therefore, in-depth research on the mechanisms of m6A and ncRNA in MM significant for diagnosis, treatment, and prognosis of MM.
N6-甲基腺苷（m6A）和非编码RNA（ncRNA）在多发性骨髓瘤（MM）的发生、发展和预后中发挥着重要作用。它们不仅影响MM细胞的干性、生长和凋亡，还干预MM的增殖、迁移、侵袭，甚至耐药性。它也是MM患者不良生存的一个预后因素。因此，深入研究m6A和ncRNA在MM中的作用机制对MM的诊断、治疗和预后具有重要意义。
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