Adipocyte-Derived , , , and Regulate Oogenesis.

In addition to energy storage, adipose tissue communication to other organs plays a key role in regulating organismal physiology. While the link between adipose tissue dysfunction and pathophysiology, including diabetes, chronic inflammation, and infertility, is clear, the molecular mechanisms that underlie these associations have not been fully described. We use as a model to better understand how adipose tissue communicates to the ovary. In this study, we utilized robust genetic toolkit to examine the role of five adipokines known to control larval growth during development, , , , , and in regulating oogenesis. We show that the adult fat body expresses these "larval" adipokines. Our data indicate that ovarian germline stem cell maintenance does not require these adipokines. However, adipocyte-derived , , , and influence early and late germline survival as well as ovulation. Thus, this work uncovers several adipokines that mediate fat-to-ovary communication.