探索生物活性全景：来自人类微生物群的肽类和非肽类物质

Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.

作者信息

Shah Abdul Bari, Cho Hyeonjae, Shim Sang Hee

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

出版信息

NPJ Biofilms Microbiomes. 2025 May 8;11(1):76. doi: 10.1038/s41522-025-00713-x.

DOI:10.1038/s41522-025-00713-x

PMID:40341751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12062242/

Abstract

The human microbiota, consisting of trillions of bacteria from six main phyla, produces peptide and non-peptide secondary metabolites which have antibacterial properties vital to medicine and biotechnology. These metabolites influence biological processes linked to diseases, yet much remains unknown. This review explores their structures and functions, aiming to spur novel metabolite discovery and advance drug development.

摘要

人类微生物群由来自六个主要门类的数万亿细菌组成，会产生具有抗菌特性的肽类和非肽类次级代谢产物，这些特性对医学和生物技术至关重要。这些代谢产物影响与疾病相关的生物过程，但仍有许多未知之处。本综述探讨了它们的结构和功能，旨在促进新型代谢产物的发现并推动药物开发。