Xu Shuting, Deo Ravinesh C, Faust Oliver, Barua Prabal D, Soar Jeffrey, Acharya Rajendra
Artificial Intelligence Applications Laboratory, School of Mathematics, Physics and Computing, University of Southern Queensland, Springfield, QLD 4300, Australia.
Cogninet Australia, Sydney, NSW 2010, Australia.
Diagnostics (Basel). 2025 May 1;15(9):1155. doi: 10.3390/diagnostics15091155.
Chronic respiratory diseases, such as asthma and COPD, pose significant challenges to human health and global healthcare systems. This pioneering study utilises AI analysis and modelling of cough and respiratory sound signals to classify and differentiate between asthma, COPD, and healthy subjects. The aim is to develop an AI-based diagnostic system capable of accurately distinguishing these conditions, thereby enhancing early detection and clinical management. Our study, therefore, presents the first AI system that leverages dual acoustic signals to enhance the diagnostic ACC of asthma using automated, lightweight deep learning models. To build an automated, lightweight model for asthma detection, tested separately with respiratory and cough sounds to assess their suitability for detecting asthma and COPD, the proposed AI models integrate the following ML algorithms: RF, SVM, DT, NN, and KNN, with an overall aim to demonstrate the efficacy of the proposed method for future clinical use. Model training and validation were performed using 5-fold cross-validation, wherein the dataset was randomly divided into five folds and the models were trained and tested iteratively to ensure robust performance. We evaluated the model outcomes with several performance metrics: ACC, precision, recall, F1 score, and area under the AUC. Additionally, a majority voting ensemble technique was employed to aggregate the predictions of the various classifiers for improved diagnostic reliability. We applied Gabor time-frequency transformation for feature extraction and NCA) for feature selection to optimise predictive accuracy. Independent comparative experiments were conducted, where cough-sound subsets were used to evaluate asthma detection capabilities, and respiratory-sound subsets were used to evaluate COPD detection capabilities, allowing for targeted model assessment. The proposed ensemble approach, facilitated by a majority voting approach for model efficacy evaluation, achieved acceptable ACC values of 94.05% and 83.31% for differentiating between asthma and normal cases utilising separate respiratory sounds and cough sounds, respectively. The results highlight a substantial benefit in integrating multiple classifier models and sound modalities while demonstrating an unprecedented level of ACC and robustness for future diagnostic predictions of the disease. The present study sets a new benchmark in AI-based detection of respiratory diseases by integrating cough and respiratory sound signals for future diagnostics. The successful implementation of a dual-sound analysis approach promises advancements in the early detection and management of asthma and COPD.We conclude that the proposed model holds strong potential to transform asthma diagnostic practices and support clinicians in their respiratory healthcare practices.
慢性呼吸道疾病,如哮喘和慢性阻塞性肺疾病(COPD),对人类健康和全球医疗系统构成了重大挑战。这项开创性研究利用人工智能对咳嗽和呼吸声音信号进行分析和建模,以对哮喘、慢性阻塞性肺疾病和健康受试者进行分类和区分。目的是开发一种基于人工智能的诊断系统,能够准确区分这些病症,从而加强早期检测和临床管理。因此,我们的研究提出了首个利用自动、轻量级深度学习模型,借助双声学信号来提高哮喘诊断准确率的人工智能系统。为构建用于哮喘检测的自动、轻量级模型,并分别使用呼吸声和咳嗽声进行测试,以评估它们对检测哮喘和慢性阻塞性肺疾病的适用性,所提出的人工智能模型整合了以下机器学习算法:随机森林(RF)、支持向量机(SVM)、决策树(DT)、神经网络(NN)和K近邻(KNN),总体目标是证明所提出方法在未来临床应用中的有效性。模型训练和验证使用5折交叉验证进行,其中数据集被随机分为五折,模型进行迭代训练和测试以确保稳健性能。我们用几个性能指标评估模型结果:准确率(ACC)、精确率、召回率、F1分数和曲线下面积(AUC)。此外,采用多数投票集成技术来汇总各个分类器的预测结果,以提高诊断可靠性。我们应用加博尔时频变换进行特征提取,并使用邻域成分分析(NCA)进行特征选择,以优化预测准确性。进行了独立对比实验,其中咳嗽声子集用于评估哮喘检测能力,呼吸声子集用于评估慢性阻塞性肺疾病检测能力,从而实现有针对性的模型评估。所提出的集成方法,通过多数投票方法促进模型效能评估,在分别利用呼吸声和咳嗽声区分哮喘与正常病例时,分别取得了94.05%和83.31%的可接受准确率值。结果突出了整合多个分类器模型和声音模态的显著益处,同时展示了前所未有的准确率水平以及对该疾病未来诊断预测的稳健性。本研究通过整合咳嗽和呼吸声音信号用于未来诊断,在基于人工智能的呼吸道疾病检测方面树立了新的标杆。双声音分析方法的成功实施有望在哮喘和慢性阻塞性肺疾病的早期检测和管理方面取得进展。我们得出结论,所提出的模型在改变哮喘诊断实践以及在呼吸医疗实践中支持临床医生方面具有强大潜力。