靶向铁死亡干预糖尿病性心肌病的潜在意义
Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy.
作者信息
Lei Qian, Yang Burton B, Lyu Juanjuan
机构信息
Anesthesia and Operation Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
J Diabetes. 2025 Jun;17(6):e70116. doi: 10.1111/1753-0407.70116.
BACKGROUND
Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained.
METHODS
Recent studies were reviewed to provide a comprehensive summary of pathogenesis and clinical treatment of DCM, effect of ferroptosis, and potential value of ferroptosis inhibitors in DCM intervention.
RESULTS
A growing body of research indicates that oxidative stress, inflammatory reactions, and other factors play a role in the onset and progression of DCM. Oxidative stress within cardiomyocytes is a primary mechanism implicated in the development of DCM, whereby heightened intracellular reactive oxygen species (ROS) facilitate cell death via ferroptosis. Ferroptosis inhibitors hold great promise as therapeutic agents.
CONCLUSIONS
This review provides an overview of the involvement of iron homeostasis regulation, oxidative stress, and ferroptosis in DCM, and the significance of ferroptosis in the prevention and treatment of DCM.
背景
糖尿病是一个重大的全球健康问题，糖尿病性心肌病（DCM）已成为糖尿病患者死亡的主要原因。尽管DCM很普遍，但治疗和预防策略的进展仍然有限。
方法
回顾近期研究，以全面总结DCM的发病机制和临床治疗、铁死亡的作用以及铁死亡抑制剂在DCM干预中的潜在价值。
结果
越来越多的研究表明，氧化应激、炎症反应和其他因素在DCM的发生和发展中起作用。心肌细胞内的氧化应激是DCM发生的主要机制，细胞内活性氧（ROS）水平升高通过铁死亡促进细胞死亡。铁死亡抑制剂作为治疗药物具有很大的潜力。
结论
本综述概述了铁稳态调节、氧化应激和铁死亡在DCM中的作用，以及铁死亡在DCM预防和治疗中的意义。
Zotero 插件