Husky Mathilde M, Lee Sue, Sampson Nancy A, Borowski Shelby, Albor Yesica, Alhadi Ahmad N, Alonso Jordi, Al-Saud Nouf K, Altwaijri Yasmin A, Andersson Claes, Atwoli Lukoye, Muaka Caroline Ayuya, Báez-Mansur Patricia M, Ballester Laura, Bantjes Jason, Baumeister Harald, Bendtsen Marcus, Benjet Corina, Berman Anne H, Bruffaerts Ronny, Carrasco Paula, Chan Silver C N, Cohut Irina F, Couder María Anabell Covarrubias Díaz, Cristóbal-Narváez Paula, Crockett Marcelo A, Cuijpers Pim, David Oana A, Dong Dong, Ebert David D, Forero Carlos G, Gaete Jorge, Gili Margalida, Gutiérrez-García Raúl, Haro Josep Maria, Hasking Penelope, Hunt Xanthe, Jaguga Florence, Jansen Leontien, Langer Álvaro I, Léniz Irene, Liu Yan, Lochner Christine, Mac-Ginty Scarlett, Martínez Vania, Mason Andre, Mathai Muthoni, McLafferty Margaret, Murray Elaine K, Musyoka Catherine M, Nedelcea Cătălin, Núñez Daniel, O'Neill Siobhan M, Piqueras José A, Popescu Codruta A, Rapsey Charlene, Robinson Kealagh, Rodriguez-Jimenez Tiscar, Saal Wylene, Scarf Damian, Siu Oi-Ling, Stein Dan J, Struijs Sascha Y, Tomoiaga Cristina T, Valdés-García Karla Patricia, Vargas-Contreras Eunice, Vereecke Shelby, Vigo Daniel V, Wang Angel Y, Wong Samuel Y S, Kessler Ronald C
Active Team, Bordeaux Population Health Research Center, INSERM U1219, University of Bordeaux, France.
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Psychiatry Res. 2025 Jun 11;351:116585. doi: 10.1016/j.psychres.2025.116585.
This study investigates associations of childhood adversities (CAs) with lifetime prevalence, 12-month prevalence, and 12-month persistence of mental disorders in a large cross-national sample of university students.
Data came from epidemiologic surveys carried out by the World Mental Health International College Student (WMH-ICS)Initiative across 18 countries (n=60,719). The web-based surveys screened for lifetime and 12-month prevalence and age-of-onset of common DSM-5 disorders (Major Depressive Disorder, Bipolar I/II Disorder, Generalized Anxiety Disorder, Panic Disorder, Posttraumatic Stress Disorder, Alcohol and Drug Use disorders, Attention-Deficit/Hyperactivity Disorder) and five types of CAs (family dysfunction, emotional abuse, physical abuse, sexual abuse, neglect). Multivariable Poisson regression models estimated associations of CA type, number, and frequency with disorders.
The majority of incoming students reported exposure to at least one CA (64.9%), including 50.0 % family dysfunction, 42.2 % emotional abuse, 21.2 % physical abuse, 18.8 % neglect, and 5.0 % sexual abuse. Lifetime and 12-month disorders were significantly associated with CAs in multivariable models, although associations with disorder persistence were weaker. Population attributable risk proportions of 12-month disorders associated with CAs were in the range of 40.7-61.0 % for anxiety and mood disorders and 13.5-55.2 % for substance use disorders.
Six out of ten university students arrive at university having been exposed to CAs. These students have substantially higher risk of mental disorders than other students, primarily due to associations with lifetime risk rather than persistence. Given the considerable distress and impairment caused by mental disorders, these results underscore the need for primary and secondary prevention efforts.
本研究在一个大型跨国大学生样本中,调查童年逆境(CA)与精神障碍的终生患病率、12个月患病率及12个月持续率之间的关联。
数据来自世界心理健康国际大学生(WMH-ICS)倡议在18个国家开展的流行病学调查(n = 60,719)。基于网络的调查筛查了常见DSM-5障碍(重度抑郁症、双相I/II型障碍、广泛性焦虑障碍、惊恐障碍、创伤后应激障碍、酒精和药物使用障碍、注意力缺陷多动障碍)的终生患病率和12个月患病率以及发病年龄,以及五种类型的童年逆境(家庭功能障碍、情感虐待、身体虐待、性虐待、忽视)。多变量泊松回归模型估计了童年逆境类型、数量和频率与障碍之间的关联。
大多数入学学生报告至少经历过一种童年逆境(64.9%),包括50.0%的家庭功能障碍、42.2%的情感虐待、21.2%的身体虐待、18.8%的忽视和5.0%的性虐待。在多变量模型中,终生和12个月的障碍与童年逆境显著相关,尽管与障碍持续率的关联较弱。与童年逆境相关的12个月障碍的人群归因风险比例在焦虑和情绪障碍中为40.7 - 61.0%,在物质使用障碍中为13.5 - 55.2%。
十分之六的大学生在进入大学时曾经历过童年逆境。这些学生患精神障碍的风险比其他学生高得多,主要是由于与终生风险的关联而非持续率。鉴于精神障碍造成的巨大痛苦和损害,这些结果强调了一级和二级预防措施的必要性。