探索患有自闭症的学童和青少年的肠脑互动障碍
Exploring Disorders of Gut-Brain Interaction in Schoolchildren and Adolescents with Autism.
作者信息
Velasco-Benítez Carlos Alberto, Rojas-Cerón Christian Andrés, Ortiz-Rivera Claudia Jimena, Velasco-Suárez Daniela Alejandra, Juvinao-Quintero María Carolina, Zubiri Cecilia Elena, Fernández Julián Martín, Bigliardi Román, Zosi Anabella, Chanis Águila Ricardo A, Guzmán Acevedo Celina, Reynoso Zarzosa Fátima Azereth, Zablah Cordova Roberto Arturo
机构信息
Departamento de Pediatría, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali 76001, Colombia.
Faculty of Health Sciences, Universidad Libre, Cali 760031, Colombia.
出版信息
Life (Basel). 2025 Jun 4;15(6):912. doi: 10.3390/life15060912.
BACKGROUND
Disorders of Gut-Brain Interaction (DGBIs) are present in 23.0% of the paediatric population, according to Rome IV. Latin American (LA) prevalence of DGBIs in children with Autism Spectrum Disorder (ASD) is unknown. The aim of this study was to determine the prevalence of DGBIs and possible associations in schoolchildren and adolescents with ASD from LA.
METHODS
An observational analytical study was conducted in LA cities. Caregivers of children with ASD completed the Rome IV Questionnaire for Pediatric Gastrointestinal Symptoms to identify DGBIs. Sociodemographic, clinical, and family variables were included. Statistical analysis involved central tendency measures, univariate and bivariate analysis, calculation odds ratios (ORs), and 95% confidence intervals (95%CIs), with < 0.05 significance.
RESULTS
The study included 353 children with ASD. Predominantly male (78.8%), white (56.1%), attending private schools (79.3%), altered nutritional status (43.9%), born by c-section (57.5%), firstborn (54.7%), level of autism not classified at the time of the study (49.0%). A total of 58.9% presented DGBI. Functional constipation (FC) was the most frequent (27.2%). Those from Central America (CA) had a higher likelihood of presenting a DGBI (OR = 1.98, 95% CI = 1.25-3.12, = 0.0018).
CONCLUSIONS
Over half of LA schoolchildren and adolescents with ASD presented DGBI, FC being the most common, and higher likelihood of DGBI in CA.
背景
根据罗马IV标准，肠道-脑互动障碍（DGBIs）在23.0%的儿科人群中存在。拉丁美洲（LA）自闭症谱系障碍（ASD）儿童中DGBIs的患病率尚不清楚。本研究的目的是确定来自LA的ASD学龄儿童和青少年中DGBIs的患病率及可能的关联。
方法
在LA城市进行了一项观察性分析研究。ASD儿童的照顾者完成了罗马IV小儿胃肠道症状问卷以识别DGBIs。纳入了社会人口统计学、临床和家庭变量。统计分析包括集中趋势测量、单变量和双变量分析、计算优势比（ORs）和95%置信区间（95%CIs），显著性水平<0.05。
结果
该研究纳入了353名ASD儿童。主要为男性（78.8%）、白人（56.1%）、就读于私立学校（79.3%）、营养状况改变（43.9%）、剖宫产出生（57.5%）、头胎（54.7%）、研究时自闭症程度未分类（49.0%）。共有58.9%的儿童出现DGBI。功能性便秘（FC）最为常见（27.2%）。来自中美洲（CA）的儿童出现DGBI的可能性更高（OR = 1.98，95% CI = 1.25 - 3.12，P = 0.0018）。
结论
LA超过一半的ASD学龄儿童和青少年出现DGBI，FC最为常见，且CA地区出现DGBI的可能性更高。
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