转录因子（SOX11）在急性髓系白血病患者骨髓中的表达的临床意义
Clinical significance of the transcription factor (SOX11) expression in the bone marrow of acute myeloid leukemia patients.
作者信息
Abdel Aziz Rania S, Radwan Enas M, Fouad Abdelhamid M, Abdellateif Mona S, Elfishawi Sally
机构信息
Clinical Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Medical Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
出版信息
World J Clin Oncol. 2025 Jun 24;16(6):107271. doi: 10.5306/wjco.v16.i6.107271.
BACKGROUND
The prognosis for acute myeloid leukemia (AML) remains poor, underscoring the need for a deeper understanding of its underlying molecular mechanisms.
AIM
To assess the significance of gene expression in the clinical features, response to treatment, and survival outcomes of adult patients with AML.
METHODS
This retrospective study enrolled 102 adults with AML. gene expression in bone marrow samples was measured using real-time PCR. Data were correlated to the patients' clinical features, response to treatment, and survival rates.
RESULTS
Increased expression was significantly associated with the presence of the mutation ( < 0.001), the FAB-M2 subtype ( = 0.008), and cytogenetic abnormalities ( = 0.011). However, no significant association was found between SOX11 expression and other clinical laboratory parameters, complete remission, disease-free survival, or overall survival.
CONCLUSION
expression may serve as a marker to identify specific subsets of AML patients who could benefit from intensive targeted chemotherapy.
背景
急性髓系白血病（AML）的预后仍然很差，这突出表明需要更深入地了解其潜在的分子机制。
目的
评估基因表达在成年AML患者的临床特征、治疗反应和生存结果中的意义。
方法
这项回顾性研究纳入了102例成年AML患者。使用实时PCR测量骨髓样本中的基因表达。数据与患者的临床特征、治疗反应和生存率相关。
结果
表达增加与突变的存在（P<0.001）、FAB-M2亚型（P = 0.008）和细胞遗传学异常（P = 0.011）显著相关。然而，未发现SOX11表达与其他临床实验室参数、完全缓解、无病生存或总生存之间存在显著关联。
结论
表达可能作为一种标志物，用于识别可能从强化靶向化疗中获益的特定AML患者亚组。
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