Sustainable Amide-Based Magnetic Dispersive Microextraction with an AQbD-Assisted Analytical Method to Detect Olanzapine from Milk-Based Food Matrices on Infusion Followed by a Green and White Assessment-Based Comparative Study.

Olanzapine is a well-known atypical, second-generation, antipsychiatric drug approved by the FDA. Recently, it is being witnessed as a party abusive drug discretely or in combination and as being an antagonist causing seduction. The current study is reported for the first time, and it focuses on a new and sustainable extraction cum detection method to effectively identify the olanzapine drug that has been deliberately infused in two different edible matrices. It entails a new magnetic dispersive microextraction method employing maleimide-coated FeO nanoparticles to selectively and significantly isolate the drug from the edible matrices, while on the other side, a reliable, efficient, analytical method was developed using AQbD (i.e., Box-Behnken design) in the presence of LC-UV and was also validated. The method's linearity at an of 0.9997 for the standard; ∼0.997 for extraction; sensitivity as 1.4 μg/mL for the LOD and 4.9 μg/mL for the LOQ; and accuracy with 97-99% recovery was proved diligently. Complementary to the study, a confirmative analysis with LC-MS was conducted for a more steadfast result. The sustainability of the method has been ensured by opting for recent and innovative evaluating tools. The three major principles of sustainability were assessed by three prominent greenness tools, a blue and red analyzing tool, and more wholly the latest RGBfast software to assess all three principles. The results were indicative of the good eco-friendliness and environmental sustainability of the method.