宫颈癌患者中PCAT1、PCAT2和PCAT3长链非编码RNA的上调及其诊断价值。
Upregulation of PCAT1, PCAT2, and PCAT3 LncRNAs in cervical cancer patients and their diagnostic value.
作者信息
Bazmi Hadi, Asghari Asma Alizadeh, Jalali Mahya Barzgar, Rezvan Leila, Panahi Zang Malek Fateme, Safaralizadeh Reza
机构信息
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Department of Plants, Cellular and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
出版信息
BMC Res Notes. 2025 Jul 25;18(1):326. doi: 10.1186/s13104-025-07401-1.
OBJECTIVE
Cervical cancer is one of the most common cancers among women. Despite advances in vaccination and screening, barriers to early detection and effective treatment remain. lncRNAs play an important role in cancer progression and therapeutic responses. New lncRNAs such as PCAT1, PCAT2, and PCAT3 have shown oncogenic activities in multiple cancers, but their role in cervical cancer is not understood. This study investigated the expression patterns of PCAT1, PCAT2, and PCAT3 in cervical cancer to evaluate their use as diagnostic markers and therapeutic targets.
RESULTS
The expression level of PCAT1, PCAT2, and PCAT3 was significantly (P value < 0.05) higher in tumor tissues.ROC analysis showed a moderate diagnostic biomarker value for PCAT1 (AUC 0.79, sensitivity 79%, specificity 69%). Spearman's analysis showed a positive correlation between PCAT1-PCAT2 and PCAT1-PCAT3. PCAT1, PCAT2, and PCAT3 lncRNAs significantly increase in cervical cancerous tissues and may play a role as novel oncogenes. Their use as clinical diagnostic markers requires further studies.
目的
宫颈癌是女性中最常见的癌症之一。尽管在疫苗接种和筛查方面取得了进展，但早期检测和有效治疗的障碍仍然存在。长链非编码RNA（lncRNAs）在癌症进展和治疗反应中发挥着重要作用。新的lncRNAs，如PCAT1、PCAT2和PCAT3，已在多种癌症中显示出致癌活性，但其在宫颈癌中的作用尚不清楚。本研究调查了PCAT1、PCAT2和PCAT3在宫颈癌中的表达模式，以评估它们作为诊断标志物和治疗靶点的用途。
结果
肿瘤组织中PCAT1、PCAT2和PCAT3的表达水平显著升高（P值<0.05）。ROC分析显示PCAT1具有中等诊断生物标志物价值（AUC 0.79，敏感性79%，特异性69%）。Spearman分析显示PCAT1与PCAT2、PCAT1与PCAT3之间呈正相关。PCAT1、PCAT2和PCAT3 lncRNAs在宫颈癌细胞组织中显著增加，可能作为新型癌基因发挥作用。它们作为临床诊断标志物的用途需要进一步研究。
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