TFR1作为慢性阻塞性肺疾病患者肺纤维化发展的生物标志物。
TFR1 as a Biomarker of Pulmonary Fibrosis Development in COPD Patients.
作者信息
Wu Yuan, Jiang Yu, Xiao Bin, Xie Lijun, Zhou Nanjiang, Zeng Aoguo, Liu Cuizhong
机构信息
Department of General Medicine, Hunan Provincial People's Hospital and The First-Affiliated of Hospital of Hunan Normal University, Changsha, 410005, People's Republic of China.
Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital and The First-Affiliated of Hospital of Hunan Normal University, Changsha, 410005, People's Republic of China.
出版信息
Int J Chron Obstruct Pulmon Dis. 2025 Aug 5;20:2715-2725. doi: 10.2147/COPD.S527782. eCollection 2025.
BACKGROUND
Ferroptosis is involved in chronic lung injury, including COPD and pulmonary fibrosis. In this study, we investigated the role of transferrin protein 1 (TFR1), as a ferroptosis marker, in the development of COPD-associated pulmonary fibrosis.
METHODS
The expression of TFR1 was elevated in 97 patients with COPD. The correlation analysis of the clinical characteristic was performed including the frequency of acute exacerbation, the fibrosis score, etc. and the expression of TFR1. Animal experiments were carried out to verify TFR1 expression in a rat COPD model.
RESULTS
The results showed that the expression of TFR1 was related to DLCO%, 6 MWT, GOLD grade, frequency of acute exacerbation and fibrosis score. Together, in the rat COPD model, higher TFR1 was related to a higher lung injury score and a higher lung fibrosis score.
CONCLUSION
In summary, these results indicated that serum TFR1 levels related to the severity of pulmonary fibrosis in clinical practice and may provide a potential target for the treatment of pulmonary fibrosis development from patients with COPD in the future.
背景
铁死亡参与慢性肺损伤，包括慢性阻塞性肺疾病（COPD）和肺纤维化。在本研究中，我们调查了转铁蛋白1（TFR1）作为铁死亡标志物在COPD相关肺纤维化发生发展中的作用。
方法
97例COPD患者的TFR1表达升高。对临床特征进行相关性分析，包括急性加重频率、纤维化评分等与TFR1表达的相关性。进行动物实验以验证大鼠COPD模型中TFR1的表达。
结果
结果表明，TFR1的表达与一氧化碳弥散量百分比（DLCO%）、6分钟步行距离（6MWT）、慢性阻塞性肺疾病全球倡议（GOLD）分级、急性加重频率和纤维化评分相关。总体而言，在大鼠COPD模型中，较高的TFR1与较高的肺损伤评分和较高的肺纤维化评分相关。
结论
总之，这些结果表明，在临床实践中血清TFR1水平与肺纤维化严重程度相关，未来可能为COPD患者肺纤维化发展的治疗提供潜在靶点。
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