动物发育过程中分泌的卷曲相关蛋白

Secreted Frizzled-related proteins in animal development.

作者信息

Sadriev Konstantin

机构信息

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.

出版信息

Histochem Cell Biol. 2025 Aug 15;163(1):80. doi: 10.1007/s00418-025-02415-z.

DOI:10.1007/s00418-025-02415-z

PMID:40815314

Abstract

Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and antagonists. As part of the intercellular communication system, they regulate signaling pathways significant for animal development including Wnt and BMP. This review summarizes the current knowledge of SFRP functions, focusing on recent discoveries that offer new insights into the role of interactions between SFRPs and Wnt signaling pathways in morphogenesis.

摘要

分泌型卷曲相关蛋白（SFRPs）是一类小型的、古老的细胞外信号通路激动剂和拮抗剂家族。作为细胞间通讯系统的一部分，它们调节对动物发育至关重要的信号通路，包括Wnt和BMP。本综述总结了目前关于SFRP功能的知识，重点关注最近的发现，这些发现为SFRP与Wnt信号通路之间的相互作用在形态发生中的作用提供了新的见解。