诱导放化疗使局部晚期肺淋巴上皮瘤样癌实现长期无复发生存：一例报告及文献综述
Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review.
作者信息
Huang Gengda, He Hong, Fan Yuting, Ren Qinqin, Jiang Huixin, Luo Li, Guo Li, Chen Haiwen, Zhang Jiexia
机构信息
Department of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
School of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China.
出版信息
Front Immunol. 2025 Jul 31;16:1605900. doi: 10.3389/fimmu.2025.1605900. eCollection 2025.
Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectiveness in pLELC remains uncertain. A female with stage IIIB pLELC was treated with 4 cycles of gemcitabine plus cisplatin, achieving partial response(PR), followed by radical radiotherapy. Patients achieved clinical complete response(CR) with recurrence-free for over five years. This case highlights the potential of induction chemotherapy as an effective treatment for locally advanced pLELC.
肺淋巴上皮瘤样癌（pLELC）是非小细胞肺癌（NSCLC）的一种罕见亚型，与爱泼斯坦-巴尔病毒（EBV）感染密切相关。虽然诱导化疗后放疗在鼻咽癌（NPC）中已显示出显著疗效，但其在pLELC中的有效性仍不确定。一名ⅢB期pLELC女性患者接受了4个周期的吉西他滨加顺铂治疗，达到部分缓解（PR），随后进行了根治性放疗。患者实现了临床完全缓解（CR），无复发生存超过五年。该病例突出了诱导化疗作为局部晚期pLELC有效治疗方法的潜力。
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