Current applications and future perspectives on rare-earth-based materials in stomatology.

A confluence of factors, including the incompatibility of conventional materials with the oral environment, inadequate dynamic response, and insufficient multi-objective synergy, hinders precise diagnosis and efficient treatment in contemporary stomatology. Due to their unique electronic configuration and multivalent properties, rare earth elements (REEs) have shown excellent optical response, enzyme simulation activity, antibacterial efficacy, and biological regulation potential. These attributes offer a promising path for developing a new generation of oral functional materials. To align the unique properties of REEs and the clinical demands, this article summarizes the current knowledge of physicochemical properties and biological functions of REEs, and provides a comprehensive overview of the cutting-edge applications of rare-earth-based materials in oral medicine. We anticipate that this review will enhance the understanding of the interdisciplinary value of rare-earth-based materials in stomatology, thereby contributing to the improvement of future oral healthcare.