肝细胞癌肿瘤微环境中CD8 T细胞的免疫代谢靶点

Immunometabolic Targets in CD8 T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma.

作者信息

Lin Yanze, Ruze Rexiati, Zhang Ruiqing, Tuergan Talaiti, Wang Maolin, Tulahong Alimu, Zhu Dalong, Yuan Zhongdian, Jiang Tiemin, Aji Tuerganaili, Shao Yingmei

机构信息

Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.

Clinical Research Center for Echinococcosis and Hepatobiliary Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.

出版信息

Liver Cancer. 2024 Nov 21;14(4):474-496. doi: 10.1159/000542578. eCollection 2025 Aug.

DOI:10.1159/000542578

PMID:40831886

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12360748/

Abstract

BACKGROUND

CD8 T cells are critical for the oncogenesis and progression of the hepatocellular carcinoma (HCC) tumor microenvironment, receiving antigen signals from antigen-presenting cells and directly contributing to antitumor responses.

SUMMARY

CD8 T cells mediate immunogenic cell death, facilitate immune signal transmission, and play a significant role in various treatments, including surgery, transarterial chemoembolization, and immunotherapy. Extensive research on the role of CD8 T cells within the HCC microenvironment has shown considerable progress. Immunometabolic targets on CD8 T cells have demonstrated potential in combination with immunotherapies for HCC; however, they have not yet reached the clinical trial stage.

KEY MESSAGES

This review provides a comprehensive overview of recent research on immune and immunometabolic targets of CD8 T cells within the HCC microenvironment. By highlighting advances and potential mechanisms, this review aims to support the development of effective clinical strategies in this field.

摘要