乳酰化在脂质代谢及相关疾病中的作用。

Roles of lactylation in lipid metabolism and related diseases.

作者信息

Zhao Bing, Lan Zhuoqing, Li Caixia, Wang Hao

机构信息

Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Department of General Practice Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.

出版信息

Cell Death Discov. 2025 Aug 23;11(1):401. doi: 10.1038/s41420-025-02705-4.

DOI:10.1038/s41420-025-02705-4

PMID:40849305

Abstract

Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.

摘要

脂质是不可或缺的分子，通过作为结构成分、能量储存库以及信号转导的参与者，在细胞生理学中发挥关键作用。最近的研究已将乳酰化鉴定为一种对维持细胞和组织平衡至关重要的新型翻译后修饰。研究表明，乳酰化调节脂质代谢所必需的蛋白质和脂质的周转。然而，缺乏针对乳酰化与脂质代谢之间复杂关系的全面综述。在本综述中，我们总结了关于乳酰化对脂质代谢的影响及其调控机制的当前研究结果。进一步探索乳酰化在脂质代谢中作用的复杂机制，以及开发针对乳酰化的疗法，可为管理与脂质代谢失调相关的疾病提供创新方法。