铂基配合物在肺癌治疗中的研究进展：作用机制、应用及挑战

Research Progress of Platinum-Based Complexes in Lung Cancer Treatment: Mechanisms, Applications, and Challenges.

作者信息

Liang Wanqi, Huang Yufeng, Wang Yi, Lu Desheng, Sun Qi

机构信息

Department of Pharmacology, International Cancer Center, Shenzhen University Medical School, Shenzhen 518060, China.

Shenzhen Key Lab of Functional Polymer, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.

出版信息

Int J Mol Sci. 2025 Aug 18;26(16):7958. doi: 10.3390/ijms26167958.

DOI:10.3390/ijms26167958

PMID:40869279

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12386309/

Abstract

Platinum-based complexes, as one of the mainstay chemotherapeutic agents in oncology, have evolved from first-generation Cisplatin to third-generation Oxaliplatin, with numerous platinum complexes currently under clinical investigation. This review systematically evaluates all existing platinum complexes for lung cancer treatment, including three generations of approved agents and investigational candidates, with comprehensive analysis of therapeutic efficacy and toxicity profiles. Our assessment aims to provide novel insights for developing next-generation platinum complexes with optimal therapeutic potential.

摘要

铂类配合物作为肿瘤学领域的主要化疗药物之一，已从第一代顺铂发展到第三代奥沙利铂，目前有众多铂类配合物正处于临床研究阶段。本综述系统评估了所有现有的用于肺癌治疗的铂类配合物，包括三代已获批药物和处于研究阶段的候选药物，并对其治疗效果和毒性特征进行了全面分析。我们的评估旨在为开发具有最佳治疗潜力的下一代铂类配合物提供新的见解。