胸腺瘤治疗13年后发生的纯红细胞再生障碍：1例报告及文献复习

Pure Red Cell Aplasia That Developed 13 Years After Thymoma Treatment: A Case Report and Literature Review.

作者信息

Kono Kento, Nakashima Kazuhisa, Tsubata Yukari, Takahashi Tsutomu, Kawakado Keita, Yanagawa Takashi, Nagasaki Makoto, Okimoto Tamio, Isobe Takeshi

机构信息

Department of Respiratory Medicine, NHO Hamada Medical Center, Hamada, Shimane, Japan.

Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

出版信息

Thorac Cancer. 2025 Sep;16(17):e70157. doi: 10.1111/1759-7714.70157.

DOI:10.1111/1759-7714.70157

PMID:40879193

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12395460/

Abstract

A 47-year-old woman was diagnosed with invasive thymoma 13 years ago. She had undergone repeated surgeries, as well as chemotherapy and radiation therapy. Chemotherapy was discontinued after the patient developed normocytic anemia, which was unresponsive to repeated blood transfusions. Bone marrow biopsy results revealed pure red cell aplasia (PRCA). Cyclosporine treatment led to improvement in PRCA; however, the patient died 3 years later from an invasive pneumococcal infection. The onset of thymoma-associated PRCA remains unpredictable, and a significant delay may occur between the diagnosis of the two conditions.

摘要

一名47岁女性13年前被诊断为侵袭性胸腺瘤。她接受了多次手术以及化疗和放疗。在患者出现正细胞性贫血且反复输血无效后，化疗停止。骨髓活检结果显示为纯红细胞再生障碍性贫血（PRCA）。环孢素治疗使PRCA有所改善；然而，患者3年后死于侵袭性肺炎球菌感染。胸腺瘤相关PRCA的发病仍然不可预测，两种疾病诊断之间可能会出现显著延迟。