Ferroptosis and iron-based therapies in infections: From pathogenesis to treatment.

is a globally prevalent multidrug-resistant pathogen that causes severe infections, particularly in immunocompromised individuals. This review focuses on the dual role of iron in infections: as a critical nutrient for bacterial growth and as a mediator of host cell ferroptosis, a form of iron-dependent cell death. We summarize how manipulates iron metabolism to induce ferroptosis in host cells, thereby promoting its own survival and pathogenicity. Additionally, we explore therapeutic strategies targeting iron metabolism, including interfering with acquisition of iron ions from the environment, disrupting bacterial iron metabolism and iron homeostasis, using ferroptosis inhibitors to suppress host cell ferroptosis, and employing high iron concentrations to induce bacterial ferroptosis. These insights provide innovative approaches to combat drug-resistant infections.