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植物、药丸与大脑:探索植物化学物质和神经药物

Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.

作者信息

Aggarwal Arnav, Rajalekshmi Resmi, Aggarwal Anshu, Agrawal Devendra K

机构信息

Loveless Academic Magnet Program, Montgomery, AL, USA.

Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

出版信息

Int J Plant Anim Environ Sci. 2025;15(3):90-114. doi: 10.26502/ijpaes.4490180. Epub 2025 Aug 4.

Abstract

Neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, spinal cord injuries, and traumatic brain injuries, represent substantial global health challenges due to their chronic and often progressive nature. While allopathic medicine offers a range of pharmacological interventions aimed at managing symptoms and mitigating disease progression, it is accompanied by limitations, including adverse side effects, the development of drug resistance, and incomplete efficacy. In parallel, phytochemicals-bioactive compounds derived from plants-are receiving increased attention for their potential neuroprotective, antioxidant, and anti-inflammatory properties. This review will explore the therapeutic landscape of neurological diseases by providing a comprehensive overview of prevalent conditions and the current allopathic treatments available. Furthermore, this review will investigate specific phytochemicals, including flavonoids, alkaloids, and terpenoids, that exhibit promise in modulating various disease pathways. Emphasis will be placed on the interactions between plant-derived compounds and prescription medications, highlighting both potential synergistic effects and possible adverse interactions. A thorough understanding of these interactions is essential for the development of integrative treatment approaches that enhance therapeutic efficacy while minimizing harm. By bridging traditional herbal medicine with contemporary pharmacotherapy, this review aims to promote a more holistic perspective on the management of neurological diseases, while also encouraging further research into safe and effective combinatory therapies.

摘要

神经疾病,如阿尔茨海默病、帕金森病、癫痫、脊髓损伤和创伤性脑损伤,因其慢性且通常呈进行性的特点,成为全球重大的健康挑战。虽然现代医学提供了一系列旨在控制症状和减缓疾病进展的药物干预措施,但也存在局限性,包括不良副作用、耐药性的产生以及疗效不彻底等问题。与此同时,植物化学物质(从植物中提取的生物活性化合物)因其潜在的神经保护、抗氧化和抗炎特性而受到越来越多的关注。本综述将通过全面概述常见病症和现有的现代医学治疗方法,探索神经疾病的治疗前景。此外,本综述将研究特定的植物化学物质,包括黄酮类化合物、生物碱和萜类化合物,这些物质在调节各种疾病途径方面显示出前景。重点将放在植物源化合物与处方药之间的相互作用上,突出潜在的协同效应和可能的不良相互作用。对这些相互作用的透彻理解对于开发综合治疗方法至关重要,这种方法既能提高治疗效果又能将危害降至最低。通过将传统草药医学与当代药物疗法相结合,本综述旨在促进对神经疾病管理的更全面观点,同时也鼓励对安全有效的联合疗法进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fa/12416909/38eb81b54ca3/nihms-2105485-f0001.jpg

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