非编码RNA对脂质代谢调控的研究进展

Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs.

作者信息

Peng Yongdong, Liu Anqi, Zhu Qifei, Liu Xiaotong, Cai Bingbing, Yan Zhiyu, Gao Jiwei, Zhu Ruchang, Wang Changfa

机构信息

Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, College of Agriculture and Biology, Liaocheng University, Liaocheng 522000, China.

出版信息

Animals (Basel). 2025 Sep 7;15(17):2621. doi: 10.3390/ani15172621.

DOI:10.3390/ani15172621

PMID:40941416

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12427337/

Abstract

Lipid metabolism is a fundamental biological process that ensures energy homeostasis and cellular integrity. This is an essential and complex biochemical process that is involved in energy storage and the maintaining of normal biological functions. Disorders of lipid metabolism are an urgent health problem, bringing about metabolic syndromes such as obesity, hepatic steatosis, adipose tissue dysfunction, diabetes, cardiovascular diseases, and certain cancers. An increasing body of research has emphasized the pivotal function of ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, in controlling lipid metabolism and associated diseases. To identify novel therapeutic targets, it is necessary to understand the molecular mechanisms by which ncRNAs are involved in the pathobiology of lipid-associated diseases. This review summarizes the research findings on the role of ncRNA in lipid metabolism and the underlying mechanisms, emphasizing their potential as therapeutic targets for lipid-related diseases.

摘要

脂质代谢是一个基本的生物学过程，它确保能量稳态和细胞完整性。这是一个至关重要且复杂的生化过程，涉及能量储存和维持正常生物学功能。脂质代谢紊乱是一个紧迫的健康问题，会引发代谢综合征，如肥胖、肝脂肪变性、脂肪组织功能障碍、糖尿病、心血管疾病和某些癌症。越来越多的研究强调了非编码RNA（ncRNAs），特别是微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）在控制脂质代谢及相关疾病中的关键作用。为了确定新的治疗靶点，有必要了解ncRNAs参与脂质相关疾病病理生物学的分子机制。本综述总结了关于ncRNA在脂质代谢中的作用及其潜在机制的研究结果，强调了它们作为脂质相关疾病治疗靶点的潜力。