酵母对两性霉素B和三种甲酯衍生物的体外敏感性比较
Comparative in vitro susceptibility of yeasts to amphotericin B and three methyl ester derivatives.
作者信息
Oblack D L, Hewitt W L, Martin W J
出版信息
Antimicrob Agents Chemother. 1981 Jan;19(1):106-9. doi: 10.1128/AAC.19.1.106.
Abstract
The in vitro antifungal activities of two N-aminoacyl derivatives of amphotericin B methyl ester (AME) were compared by tube dilution with those of amphotericin B and AME, using 60 isolates representing 10 yeast species. A total of 70% of the strains were inhibited by concentrations of the N-aminoacyl AME derivatives that were within a twofold dilution of the amphotericin B or AME minimum inhibitory concentration. The fungicidal activity of the N-aminoacyl AME derivatives was 3- to 16-fold lower than that of amphotericin B for 8 of 10 species. A considerable spectrum of antifungal activity was observed for N-aminoacyl derivatives of AME, which represents a new class of water-soluble polyene antibiotics.
摘要
通过试管稀释法，比较了两性霉素B甲酯（AME）的两种N-氨酰基衍生物与两性霉素B和AME对代表10种酵母菌种的60株分离菌的体外抗真菌活性。在两性霉素B或AME最低抑菌浓度的两倍稀释范围内，N-氨酰基AME衍生物的浓度可抑制70%的菌株。对于10种中的8种，N-氨酰基AME衍生物的杀菌活性比两性霉素B低3至16倍。观察到AME的N-氨酰基衍生物具有相当广泛的抗真菌活性谱，它代表了一类新型的水溶性多烯抗生素。
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