正常妊娠和子痫前期患者的脑钠肽及心房钠尿肽水平

Brain natriuretic peptide and atrial natriuretic peptide levels in normal pregnancy and preeclampsia.

作者信息

Furuhashi N, Kimura H, Nagae H, Yajima A, Kimura C, Saito T

机构信息

Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Gynecol Obstet Invest. 1994;38(2):73-7. doi: 10.1159/000292452.

DOI:10.1159/000292452

PMID:7959344

Abstract

Brain natriuretic peptide (BNP) was increased in many hypertensive subjects. In this study, we have evaluated maternal, umbilical plasma and amniotic fluid BNP and atrial natriuretic peptide (ANP) in 19 normotensive pregnant women and in 35 preeclamptic patients. The maternal plasma and umbilical cord plasma ANP (p < 0.05) and BNP (p < 0.005) levels were significantly higher than those in normal pregnancy. There was no significant correlation among ANP level, BNP level, clinical symptoms and laboratory examinations. It is suggested that ANP and BNP may be rather a sequel to preeclamptic pathophysiological changes, and may not play an important role as the etiological factor of preeclampsia.

摘要

脑钠肽（BNP）在许多高血压患者中升高。在本研究中，我们评估了19名血压正常的孕妇和35名先兆子痫患者的母体、脐血浆及羊水BNP和心钠素（ANP）。母体血浆和脐血血浆中的ANP（p<0.05）和BNP（p<0.005）水平显著高于正常妊娠者。ANP水平、BNP水平、临床症状及实验室检查之间无显著相关性。提示ANP和BNP可能是先兆子痫病理生理变化的结果，而可能并非作为先兆子痫的病因发挥重要作用。