番荔枝二烯素，从番荔枝科植物中分离出的首个含有两个双键的番荔枝乙酰精。

Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae.

作者信息

Meneses da Silva E L, Roblot F, Mahuteau J, Cavé A

机构信息

Laboratoire de Pharmacognosie et Service de RMN, Faculté de Pharmacie, Châtenay-Malabry, France.

出版信息

J Nat Prod. 1996 May;59(5):528-30. doi: 10.1021/np960079e.

DOI:10.1021/np960079e

PMID:8778244

Abstract

A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.

摘要

一种新的番荔枝科乙酰精，樟叶番荔枝素（1），已从樟叶番荔枝（番荔枝科）的根中分离出来。该结构是首次报道的含有两个双键的乙酰精。化合物1对VERO和KB细胞系显示出强大的细胞毒性。化合物1似乎在单-和双-THF乙酰精的生物合成途径中起重要作用，并被提议作为樟叶番荔枝素的生物合成前体。一种已知具有细胞毒性的乙酰精，巨盘木宁，也从该植物中分离出来。