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[一所无传染病隔离病房的大学医院中结核病患者管理的实际状况]

[Actual status of the management of tuberculosis patients in a university hospital without isolation wards for infectious diseases].

作者信息

Kako K, Sakakibara H, Satou M, Kamidaira T, Suetsugu S

机构信息

Department of Pulmonology and Allergology, Fujita Health University School of Medicine, Aichi, Japan.

出版信息

Kekkaku. 1997 Jun;72(6):395-401.

PMID:9248273
Abstract

We retrospectively evaluated clinical findings and the actual status of management of 69 tuberculosis patients admitted to the Fujita Health University Hospital, a hospital without isolation wards for infectious diseases, between 1991 and 1994. The largest age group was 60s (27.5%) followed by 70s (24.6%), 80s (15.9%) and 50s (13.0%). Eight patients (11.6%) were in the 20s. Forty-nine patients were smear-positive and 22 patients were smear-negative and culture-positive. Fourteen patients (20.3%) had a past history of pulmonary tuberculosis. Twelve patients (17.4%) also had diabetes mellitus, ten patients (14.5%) had cancer, ten patients (14.5%) gastric ulcer and five patients (7.2%) renal failure. Positive skin reaction to PPD was not found in eleven patients (15.9%) and seven of these patients were quite elderly (over 70 years old). Twenty-five cases (36.2%) were classified as type II (cavitary) and 29 cases (42.0%) as type III (non-cavitary) according to the GAKKAI classification of findings on chest X-ray films for pulmonary tuberculosis. Twenty-four patients (34.8%) were not diagnosed as tuberculosis on admission by physicians in charge. Physicians in charge tended not to suspect smear-negative patients of tuberculosis. Most of the patients with cavities on their chest X-ray films were strongly suspected of tuberculosis on admission, but in some of them, tuberculosis was not considered at all. Smear-positive patients with strongly suspected tuberculosis were diagnosed with the disease within three hospital days, while it took about three weeks in patients who were not considered as tuberculosis on admission to be diagnosed as tuberculosis. In the case of smear-negative patients, it took about one month and two months respectively to diagnose the case as tuberculosis. About half (51.1%) of the smear-positive patients were admitted and treated in single-bed rooms while 44.7% were attended in multiple-bed rooms for 11 days before they were transfered to single-bed rooms. When acid-fast bacilli were detected, 57.4% of the smear-positive patients were transfered to hospitals with isolation wards for infectious diseases, while the remaining smear-positive patients were treated in single-bed rooms at the university hospital. About one-third (31.7%) of the smear-negative patients had already left the hospital when specimens were found to be culture positive for tubercle bacilli. In conclusion, it is utmost important for physicians to suspect tuberculosis for the early diagnosis of the disease.

摘要

我们回顾性评估了1991年至1994年间入住藤田保健大学医院的69例结核病患者的临床症状及实际治疗情况。该医院没有传染病隔离病房。年龄最大的组为60多岁(27.5%),其次是70多岁(24.6%)、80多岁(15.9%)和50多岁(13.0%)。8例患者(11.6%)为20多岁。49例患者痰涂片阳性,22例患者痰涂片阴性但培养阳性。14例患者(20.3%)有肺结核病史。12例患者(17.4%)患有糖尿病,10例患者(14.5%)患有癌症,10例患者(14.5%)患有胃溃疡,5例患者(7.2%)患有肾衰竭。11例患者(15.9%)结核菌素纯蛋白衍生物皮肤试验反应阴性,其中7例为高龄患者(70岁以上)。根据肺结核胸部X线片表现的日本结核病学会分类,25例(36.2%)为Ⅱ型(空洞型),29例(42.0%)为Ⅲ型(非空洞型)。24例患者(34.8%)入院时主管医生未诊断为结核病。主管医生往往不怀疑痰涂片阴性的患者患有结核病。大多数胸部X线片有空洞的患者入院时被高度怀疑患有结核病,但其中一些患者根本未被考虑患有结核病。痰涂片阳性且高度怀疑患有结核病的患者在入院三天内被确诊,而入院时未被考虑患有结核病的患者确诊则需要大约三周时间。对于痰涂片阴性的患者,确诊分别需要大约一个月和两个月时间。大约一半(51.1%)的痰涂片阳性患者被安排在单人病房入院治疗,而44.7%的患者在多人病房接受治疗11天后才被转至单人病房。当检测到抗酸杆菌时,57.4%的痰涂片阳性患者被转至有传染病隔离病房的医院,其余痰涂片阳性患者在大学医院单人病房接受治疗。约三分之一(31.7%)的痰涂片阴性患者在结核杆菌培养标本呈阳性时已出院。总之,医生怀疑结核病对于该病的早期诊断至关重要。

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