p53/p21（WAF1/CIP1）表达及其在鞣花酸处理的癌细胞中G1期阻滞和凋亡中的可能作用。
p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells.
作者信息
Narayanan B A, Geoffroy O, Willingham M C, Re G G, Nixon D W
机构信息
Cancer Prevention Program, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA.
出版信息
Cancer Lett. 1999 Mar 1;136(2):215-21. doi: 10.1016/s0304-3835(98)00323-1.
Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.
鞣花酸是一种存在于多种水果和坚果中的酚类化合物，这些水果和坚果包括树莓、草莓和核桃。已知它能抑制某些致癌物诱发的癌症，并且可能具有其他化学预防特性。我们研究了鞣花酸对子宫颈癌细胞（CaSki细胞）的细胞周期事件和细胞凋亡的影响。我们发现，浓度为10⁻⁵ M的鞣花酸在48小时内诱导G期阻滞，抑制细胞总体生长，并在处理72小时后诱导CaSki细胞凋亡。鞣花酸对细胞周期抑制蛋白p21的激活表明鞣花酸在癌细胞的细胞周期调控中发挥作用。
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