人类血液中主要的1型干扰素产生细胞的性质。

The nature of the principal type 1 interferon-producing cells in human blood.

作者信息

Siegal F P, Kadowaki N, Shodell M, Fitzgerald-Bocarsly P A, Shah K, Ho S, Antonenko S, Liu Y J

机构信息

Saint Vincents Hospital and Medical Center, New York, NY 10011, USA.

出版信息

Science. 1999 Jun 11;284(5421):1835-7. doi: 10.1126/science.284.5421.1835.

DOI:10.1126/science.284.5421.1835

PMID:10364556

Abstract

Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.

摘要

干扰素（IFN）是抗病毒免疫反应中最重要的细胞因子。人类血液中的“天然干扰素产生细胞”（IPC）表达CD4和主要组织相容性复合体II类蛋白，但由于其稀有性、快速凋亡以及缺乏谱系标记，尚未被分离和进一步鉴定。本文显示纯化的IPC是CD4(+)CD11c- 2型树突状细胞前体（pDC2），在受到微生物攻击后，其产生的干扰素比其他血细胞多200至1000倍。因此，pDC2是免疫系统的一种效应细胞类型，对抗病毒和抗肿瘤免疫反应至关重要。