日本丙型肝炎病毒相关慢性肝病患者中抗乙型肝炎病毒血清学标志物的高流行率。
High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan.
作者信息
Marusawa H, Osaki Y, Kimura T, Ito K, Yamashita Y, Eguchi T, Kudo M, Yamamoto Y, Kojima H, Seno H, Moriyasu F, Chiba T
机构信息
Division of Gastroenterology and Hepatology, Department of Medicine, Postgraduate School of Medicine, Kyoto University, Kyoto, Japan.
出版信息
Gut. 1999 Aug;45(2):284-8. doi: 10.1136/gut.45.2.284.
BACKGROUND/AIMS: Evidence is accumulating that hepatitis B virus (HBV) is present in patients who are hepatitis B surface antigen negative but have antibody to hepatitis B core antigen (anti-HBc). Furthermore, recent studies have shown that patients with hepatocellular carcinoma who have antibody to hepatitis C virus (HCV) often possess HBV related serological markers. Data on the seroprevalence of HBV infection in patients with HCV related chronic liver disease were collected to evaluate the significance of the presence of antibodies to HBV.
METHODS
The prevalence of HBV related serological markers was analysed in a total of 2014 Japanese patients with HCV infection. The control group comprised 352 subjects without liver disorder.
RESULTS
A large number of patients (49.9%) with HCV related chronic liver disease including hepatocellular carcinoma were positive for anti-HBc. In addition, the prevalence of anti-HBc closely correlated with the clinical stage of the liver disease. There was no relation between a past history of blood transfusion and the prevalence of anti-HBc. Notably, anti-HBc was the only serological marker for HBV infection in a significant number of patients with HCV related chronic liver disease (24.1%).
CONCLUSIONS
Our data provide further evidence for the high prevalence of anti-HBc in patients with HCV related chronic liver disease, particularly those with hepatocellular carcinoma, suggesting that HBV infection, probably including latent infection, may play an important role in carcinogenesis in these patients.
背景/目的：越来越多的证据表明，在乙肝表面抗原阴性但乙肝核心抗体（抗-HBc）阳性的患者体内存在乙肝病毒（HBV）。此外，最近的研究表明，丙型肝炎病毒（HCV）抗体阳性的肝细胞癌患者常伴有HBV相关血清学标志物。收集HCV相关慢性肝病患者中HBV感染的血清流行率数据，以评估HBV抗体存在的意义。
方法
分析了总共2014例日本HCV感染患者中HBV相关血清学标志物的流行情况。对照组包括352名无肝脏疾病的受试者。
结果
包括肝细胞癌在内的大量HCV相关慢性肝病患者（49.9%）抗-HBc呈阳性。此外，抗-HBc的流行率与肝病的临床分期密切相关。既往输血史与抗-HBc的流行率之间无关联。值得注意的是，在大量HCV相关慢性肝病患者（24.1%）中，抗-HBc是HBV感染的唯一血清学标志物。
结论
我们的数据进一步证明了抗-HBc在HCV相关慢性肝病患者中，尤其是肝细胞癌患者中的高流行率，这表明HBV感染，可能包括潜伏感染，可能在这些患者的致癌过程中起重要作用。
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