使用果胶：壳聚糖：羟丙基甲基纤维素薄膜包衣片将药物选择性递送至结肠。

Selective drug delivery to the colon using pectin:chitosan:hydroxypropyl methylcellulose film coated tablets.

作者信息

Macleod G S, Fell J T, Collett J H, Sharma H L, Smith A M

机构信息

School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.

出版信息

Int J Pharm. 1999 Oct 5;187(2):251-7. doi: 10.1016/s0378-5173(99)00196-9.

DOI:10.1016/s0378-5173(99)00196-9

PMID:10502631

Abstract

A study has been carried out to assess the potential of pectin:chitosan:hydroxypropyl methylcellulose (HPMC) (P:C:H) films for colonic drug delivery. Radiolabelled (99mTc) tablets were coated with a 3:1:1, P:C:H film and administered to human volunteers. The gastro-intestinal transit of the tablets was assessed by gamma scintigraphy. The results showed that in all cases (n=4), the tablets were able to pass through the stomach and small intestine intact. Break up of the tablets commenced once they were in the colon, due to degradation of the coat by colonic bacteria. The study has highlighted the potential of this coating system for colonic drug delivery.

摘要

已开展一项研究，以评估果胶：壳聚糖：羟丙基甲基纤维素（HPMC）（P:C:H）薄膜用于结肠给药的潜力。用3:1:1的P:C:H薄膜包衣放射性标记（99mTc）片剂，并将其给予人类志愿者。通过γ闪烁扫描术评估片剂在胃肠道的转运情况。结果表明，在所有病例（n = 4）中，片剂均能完整通过胃和小肠。一旦片剂进入结肠，由于结肠细菌对包衣的降解作用，片剂开始崩解。该研究突出了这种包衣系统用于结肠给药的潜力。