秀丽隐杆线虫EXP-2钾通道中的一种突变会改变进食行为。
A mutation in the C. elegans EXP-2 potassium channel that alters feeding behavior.
作者信息
Davis M W, Fleischhauer R, Dent J A, Joho R H, Avery L
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
出版信息
Science. 1999 Dec 24;286(5449):2501-4. doi: 10.1126/science.286.5449.2501.
Abstract
The nematode pharynx has a potassium channel with unusual properties, which allows the muscles to repolarize quickly and with the proper delay. Here, the Caenorhabditis elegans exp-2 gene is shown to encode this channel. EXP-2 is a Kv-type (voltage-activated) potassium channel that has inward-rectifying properties resembling those of the structurally dissimilar human ether-à-go-go-related gene (HERG) channel. Null and gain-of-function mutations affect pharyngeal muscle excitability in ways that are consistent with the electrophysiological behavior of the channel, and thereby demonstrate a direct link between the kinetics of this unusual channel and behavior.
摘要
线虫咽部有一个具有特殊性质的钾通道，它能使肌肉快速且以适当延迟进行复极化。在此，秀丽隐杆线虫的exp-2基因被证明编码此通道。EXP-2是一种Kv型（电压激活型）钾通道，具有内向整流特性，类似于结构不同的人类去极化相关基因（HERG）通道。无效突变和功能获得性突变以与该通道电生理行为一致的方式影响咽部肌肉兴奋性，从而证明了这种特殊通道的动力学与行为之间的直接联系。
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