全身化疗

Systemic chemotherapy.

作者信息

Klimek V M, Wolchok J D, Chapman P B, Houghton A N, Hwu W J

机构信息

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

出版信息

Clin Plast Surg. 2000 Jul;27(3):451-61, ix-x.

PMID:10941565

Abstract

The main use of systemic chemotherapy in metastatic melanoma remains palliative. Dacarbazine (dimethyl-1-triazeno imidazole-4-carboxamide [DTIC]) is the standard chemotherapy agent for advanced disease. The combination chemotherapy and biochemotherapy regimens have achieved higher response rates, but have not led to durable remission or improved survival. The field of systemic therapy remains in need of a more effective and less toxic treatment strategy.

摘要

全身化疗在转移性黑色素瘤中的主要用途仍然是姑息性的。达卡巴嗪（二甲基-1-三氮烯咪唑-4-甲酰胺[DTIC]）是晚期疾病的标准化疗药物。联合化疗和生物化疗方案已取得更高的缓解率，但尚未导致持久缓解或改善生存率。全身治疗领域仍需要一种更有效且毒性更小的治疗策略。