甲状腺转录因子2（TTF-2）是一种启动子特异性的、不依赖DNA结合的转录抑制因子。
The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor.
作者信息
Perrone L, Pasca di Magliano M, Zannini M, Di Lauro R
机构信息
Stazione Zoologica "Anton Dohrn,", Naples, 80121, Italy.
出版信息
Biochem Biophys Res Commun. 2000 Aug 18;275(1):203-8. doi: 10.1006/bbrc.2000.3232.
The thyroid transcription factor TTF-2 is a forkhead-containing protein involved in thyroid-specific gene expression and necessary for thyroid morphogenesis. In this paper, we demonstrate that TTF-2 is able to inhibit the activity of the thyroid-specific transcription factors TTF-1 and Pax-8 only on certain promoters. We identified the minimal protein domain responsible for repressor activity, which behaves as an independent functional domain, and we show that repression by TTF-2 is DNA-binding independent. We suggest that TTF-2 is able to interfere with a specific cofactor required for TTF-1 and Pax-8 activity.
甲状腺转录因子TTF-2是一种含叉头结构域的蛋白质，参与甲状腺特异性基因表达，对甲状腺形态发生至关重要。在本文中，我们证明TTF-2仅在某些启动子上能够抑制甲状腺特异性转录因子TTF-1和Pax-8的活性。我们鉴定出了负责抑制活性的最小蛋白质结构域，其表现为一个独立的功能结构域，并且我们表明TTF-2的抑制作用不依赖于DNA结合。我们认为TTF-2能够干扰TTF-1和Pax-8活性所需的一种特定辅因子。
Zotero 插件