1996 - 1999年越南和泰国腹泻病原体的抗生素耐药性比较
Comparative antibiotic resistance of diarrheal pathogens from Vietnam and Thailand, 1996-1999.
作者信息
Isenbarger Daniel W, Hoge Charles W, Srijan Apichai, Pitarangsi Chittima, Vithayasai Niyada, Bodhidatta Ladaporn, Hickey Kimberly W, Cam Phung Dac
机构信息
Armed Forces Research Institute of Medical Science, Bangkok, Thailand.
出版信息
Emerg Infect Dis. 2002 Feb;8(2):175-80. doi: 10.3201/eid0802.010145.
Antimicrobial resistance rates for shigella, campylobacter, nontyphoidal salmonella, and enterotoxigenic Escherichia coli were compared for Vietnam and Thailand from 1996 to 1999. Resistance to trimethoprim-sulfamethoxazole, ampicillin, chloramphenicol, and tetracycline was common. Quinolone resistance remains low in both countries, except among campylobacter and salmonella organisms in Thailand. Nalidixic acid resistance among salmonellae has more than doubled since 1995 (to 21%) in Thailand but is not yet documented in Vietnam. Resistance to quinolones correlated with resistance to azithromycin in both campylobacter and salmonella in Thailand. This report describes the first identification of this correlation and its epidemiologic importance among clinical isolates. These data illustrate the growing magnitude of antibiotic resistance and important differences between countries in Southeast Asia.
1996年至1999年期间，对越南和泰国的志贺氏菌、弯曲杆菌、非伤寒沙门氏菌和产肠毒素大肠杆菌的抗菌药物耐药率进行了比较。对甲氧苄啶-磺胺甲恶唑、氨苄青霉素、氯霉素和四环素耐药很常见。喹诺酮耐药率在两国仍然较低，但泰国的弯曲杆菌和沙门氏菌属除外。自1995年以来，泰国沙门氏菌对萘啶酸的耐药率增加了一倍多（达到21%），但越南尚无相关记录。在泰国，弯曲杆菌和沙门氏菌中对喹诺酮的耐药与对阿奇霉素的耐药相关。本报告首次描述了这种相关性及其在临床分离株中的流行病学重要性。这些数据说明了抗生素耐药性问题日益严重，以及东南亚国家之间存在的重要差异。
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