器官发生：肾小管发生的分子机制

Organogenesis: molecular mechanisms of tubulogenesis.

作者信息

Hogan Brigid L M, Kolodziej Peter A

机构信息

Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt Medical Center, Nashville, Tennessee 37232-2175, USA.

出版信息

Nat Rev Genet. 2002 Jul;3(7):513-23. doi: 10.1038/nrg840.

DOI:10.1038/nrg840

PMID:12094229

Abstract

As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behaviour, including cell polarization, tube migration to target sites, cell-fate diversification and localization of specialized cells to different regions of the tube system. Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.

摘要

随着生物体在大小和复杂性上的进化，管状系统得以发展，以实现物质在组织内外的高效运输。这些管状系统是通过基于细胞行为共同要素的策略生成的，包括细胞极化、向靶位点的管迁移、细胞命运多样化以及将特化细胞定位到管系统的不同区域。本文通过无脊椎动物和脊椎动物系统的实例，强调了在理解这些基本原则方面取得的进展，并简要讨论了调节管状系统形态发生策略的可能进化。