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用于药物递送的树枝状聚合物大分子载体。

Dendritic polymer macromolecular carriers for drug delivery.

作者信息

Patri Anil K, Majoros István J, Baker James R

机构信息

Center for Biologic Nanotechnology, Department of Internal Medicine, 9220C MSRB III, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-0648, USA.

出版信息

Curr Opin Chem Biol. 2002 Aug;6(4):466-71. doi: 10.1016/s1367-5931(02)00347-2.

Abstract

Dendrimers are synthetic, highly branched, mono-disperse macromolecules of nanometer dimensions. Started in the mid-1980s, the research investigations into the synthetic methodology, physical and chemical properties of these macromolecules are increasing exponentially with growing interest in this field. Potential applications for dendrimers are now forthcoming. Properties associated with these dendrimers such as uniform size, water solubility, modifiable surface functionality and available internal cavities make them attractive for biological and drug-delivery applications.

摘要

树枝状大分子是合成的、高度分支的、纳米尺寸的单分散大分子。自20世纪80年代中期开始,随着对该领域兴趣的不断增加,对这些大分子的合成方法、物理和化学性质的研究呈指数级增长。树枝状大分子的潜在应用现已出现。与这些树枝状大分子相关的特性,如尺寸均匀、水溶性、可修饰的表面功能和可用的内部空腔,使其在生物和药物递送应用中具有吸引力。

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