蛋白酶体激活剂PA28在MHC I类抗原加工中的作用。

The role of the proteasome activator PA28 in MHC class I antigen processing.

作者信息

Sijts Alice, Sun Yuancheng, Janek Katarina, Kral Sylvie, Paschen Annettte, Schadendorf Dirk, Kloetzel Peter-M

机构信息

Institut für Biochemie, Charité-Medizinische Fakültät der, Humboldt Universität zu Berlin, Monbijoustrasse 2, 10117 Berlin, Germany.

出版信息

Mol Immunol. 2002 Oct;39(3-4):165-9. doi: 10.1016/s0161-5890(02)00099-8.

DOI:10.1016/s0161-5890(02)00099-8

PMID:12200048

Abstract

The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-gamma. Two of these are the alpha and beta subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen.

摘要

蛋白酶体系统是主要组织相容性复合体I类（MHC I类）分子呈递的病毒抗原和肿瘤抗原产生的主要来源。蛋白酶体抗原加工机制的一个特定特征是其五个组分可被γ干扰素诱导。其中两个是蛋白酶体激活剂PA28的α和β亚基。我们的结果表明，PA28选择性地上调病毒MHC I类表位的呈递，并且在肿瘤细胞中下调PA28会导致人TRP2肿瘤抗原的呈递受损。