Boero R, Prodi E, Borsa S, Berti V, Fiorio E, Ferraro L, Massara C, Quarello F
S.C. Nefrologia e Dialisi, Ospedale San Giovanni Bosco, Torino. robertoboero@tin.,it
G Ital Nefrol. 2002 Jul-Aug;19(4):413-8.
Aim of this study is to evaluate the treatment and control of arterial hypertension in patients with type 2 diabetes.
We identified 5815 diabetic patients in our health-care district (191,568 inhabitants) through prescriptions for insulin and/or hypoglycaemic drugs in the first 6 months of 2000; 3810 of them (65%) also had prescriptions for antihypertensive drugs. We evaluated a randomly selected sample of 171 patients with type 2 diabetes, 100 of whom were receiving antihypertensive drugs (94 males and 77 females, mean age 66.6 +/- 8 years, mean diabetes duration 12+/-9 years).
Fifty-seven out of 71 patients not treated with antihypertensive drugs (80.3%) had a BP = 130/85 mmHg; 24.4% of them had a diastolic BP = 85 mmHg and 79% had a systolic BP = 130 mmHg. Thirteen out of 100 treated patients (13%) had a BP < 130/85 mmHg. Among the patients treated with antihypertensive drugs 36% received one drug, 36% two drugs and 28%=3 drugs; mean 1.98 +/- 0.9 drugs/patients. Among the patients treated with monotherapy 36.1% received ACE-inhibitors, 36.1% dihydropyridinic calcium-antagonists, 11.1% alpha-blockers, 11%, diuretics, 2.8% non-dihydropyridinic calcium-antagonists, and 2.8% angiotensin II antagonists. Patients treated with two antihypertensive drugs received more frequently an ACE-inhibitor plus a diuretic (31%) or an ACE-inhibitor plus an alpha-blocker (23%) or an ACE-inhibitor plus a dihydropyridinic calcium-antagonists (20%). A diuretic was used in 40% of the patients with two antihypertensive drugs and in 78% of those with >= 3 drugs.
Many hypertensive type 2 diabetic patients are left untreated and only a minority of those treated reach optimal blood pressure control. The importance of an elevated systolic pressure is underestimated, and the number of antihypertensive drugs prescribed is suboptimal.
本研究旨在评估2型糖尿病患者动脉高血压的治疗与控制情况。
通过2000年上半年胰岛素和/或降糖药物处方,我们在本医疗保健区(191,568名居民)识别出5815名糖尿病患者;其中3810名(65%)也有抗高血压药物处方。我们评估了171名2型糖尿病患者的随机样本,其中100名正在接受抗高血压药物治疗(男性94名,女性77名,平均年龄66.6±8岁,平均糖尿病病程12±9年)。
71名未接受抗高血压药物治疗的患者中,57名(80.3%)血压≥130/85 mmHg;其中24.4%舒张压≥85 mmHg,79%收缩压≥130 mmHg。100名接受治疗的患者中,13名(13%)血压<130/85 mmHg。在接受抗高血压药物治疗的患者中,36%服用一种药物,36%服用两种药物,28%服用三种药物;平均每位患者服用1.98±0.9种药物。在接受单一疗法的患者中,36.1%服用ACE抑制剂,36.1%服用二氢吡啶类钙拮抗剂,11.1%服用α受体阻滞剂,11%服用利尿剂,2.8%服用非二氢吡啶类钙拮抗剂,2.8%服用血管紧张素II拮抗剂。接受两种抗高血压药物治疗的患者更常服用ACE抑制剂加利尿剂(31%)或ACE抑制剂加α受体阻滞剂(23%)或ACE抑制剂加二氢吡啶类钙拮抗剂(20%)。40%接受两种抗高血压药物治疗的患者和78%接受三种及以上药物治疗的患者使用了利尿剂。
许多高血压2型糖尿病患者未接受治疗,接受治疗的患者中只有少数达到最佳血压控制。收缩压升高的重要性被低估,抗高血压药物的处方数量未达最佳。