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2型糖尿病患者动脉高血压的治疗与控制不足

[Inadequate treatment and control of arterial hypertension in patients with type 2 diabetes mellitus].

作者信息

Boero R, Prodi E, Borsa S, Berti V, Fiorio E, Ferraro L, Massara C, Quarello F

机构信息

S.C. Nefrologia e Dialisi, Ospedale San Giovanni Bosco, Torino. robertoboero@tin.,it

出版信息

G Ital Nefrol. 2002 Jul-Aug;19(4):413-8.

Abstract

BACKGROUND

Aim of this study is to evaluate the treatment and control of arterial hypertension in patients with type 2 diabetes.

METHODS

We identified 5815 diabetic patients in our health-care district (191,568 inhabitants) through prescriptions for insulin and/or hypoglycaemic drugs in the first 6 months of 2000; 3810 of them (65%) also had prescriptions for antihypertensive drugs. We evaluated a randomly selected sample of 171 patients with type 2 diabetes, 100 of whom were receiving antihypertensive drugs (94 males and 77 females, mean age 66.6 +/- 8 years, mean diabetes duration 12+/-9 years).

RESULTS

Fifty-seven out of 71 patients not treated with antihypertensive drugs (80.3%) had a BP = 130/85 mmHg; 24.4% of them had a diastolic BP = 85 mmHg and 79% had a systolic BP = 130 mmHg. Thirteen out of 100 treated patients (13%) had a BP < 130/85 mmHg. Among the patients treated with antihypertensive drugs 36% received one drug, 36% two drugs and 28%=3 drugs; mean 1.98 +/- 0.9 drugs/patients. Among the patients treated with monotherapy 36.1% received ACE-inhibitors, 36.1% dihydropyridinic calcium-antagonists, 11.1% alpha-blockers, 11%, diuretics, 2.8% non-dihydropyridinic calcium-antagonists, and 2.8% angiotensin II antagonists. Patients treated with two antihypertensive drugs received more frequently an ACE-inhibitor plus a diuretic (31%) or an ACE-inhibitor plus an alpha-blocker (23%) or an ACE-inhibitor plus a dihydropyridinic calcium-antagonists (20%). A diuretic was used in 40% of the patients with two antihypertensive drugs and in 78% of those with >= 3 drugs.

CONCLUSIONS

Many hypertensive type 2 diabetic patients are left untreated and only a minority of those treated reach optimal blood pressure control. The importance of an elevated systolic pressure is underestimated, and the number of antihypertensive drugs prescribed is suboptimal.

摘要

背景

本研究旨在评估2型糖尿病患者动脉高血压的治疗与控制情况。

方法

通过2000年上半年胰岛素和/或降糖药物处方,我们在本医疗保健区(191,568名居民)识别出5815名糖尿病患者;其中3810名(65%)也有抗高血压药物处方。我们评估了171名2型糖尿病患者的随机样本,其中100名正在接受抗高血压药物治疗(男性94名,女性77名,平均年龄66.6±8岁,平均糖尿病病程12±9年)。

结果

71名未接受抗高血压药物治疗的患者中,57名(80.3%)血压≥130/85 mmHg;其中24.4%舒张压≥85 mmHg,79%收缩压≥130 mmHg。100名接受治疗的患者中,13名(13%)血压<130/85 mmHg。在接受抗高血压药物治疗的患者中,36%服用一种药物,36%服用两种药物,28%服用三种药物;平均每位患者服用1.98±0.9种药物。在接受单一疗法的患者中,36.1%服用ACE抑制剂,36.1%服用二氢吡啶类钙拮抗剂,11.1%服用α受体阻滞剂,11%服用利尿剂,2.8%服用非二氢吡啶类钙拮抗剂,2.8%服用血管紧张素II拮抗剂。接受两种抗高血压药物治疗的患者更常服用ACE抑制剂加利尿剂(31%)或ACE抑制剂加α受体阻滞剂(23%)或ACE抑制剂加二氢吡啶类钙拮抗剂(20%)。40%接受两种抗高血压药物治疗的患者和78%接受三种及以上药物治疗的患者使用了利尿剂。

结论

许多高血压2型糖尿病患者未接受治疗,接受治疗的患者中只有少数达到最佳血压控制。收缩压升高的重要性被低估,抗高血压药物的处方数量未达最佳。

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