Lodolce James, Burkett Patrick, Koka Rima, Boone David, Chien Marcia, Chan Faye, Madonia Michelle, Chai Sophia, Ma Averil
Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue MC 6084, Chicago, IL 60637, USA.
Mol Immunol. 2002 Dec;39(9):537-44. doi: 10.1016/s0161-5890(02)00211-0.
Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions.