[压力与海马体]

[Stress and hippocampus].

作者信息

Cai Wei-xiong, Yang De-sen

机构信息

Institute of Forensic Sciences, Ministry of Justice, P. R. China, Shanghai, 200063.

出版信息

Fa Yi Xue Za Zhi. 2002 Feb;18(1):48-51.

PMID:12596585

Abstract

This review summarizes the present advance of effects of stress on hippocampal structure and function and the role of hippocampus in feedback regulation of thalamic-pituitary-adrenocortical (HPA) axis during stress. It shows that stress can affect hippocampal structure and function, on the other hand, the hippocampus can also suppress the stress reaction through the feedback regulation of HPA axis, but chronic stress can attenuate this regulation, then significantly impair its structure and function.

摘要

本综述总结了应激对海马结构和功能的影响以及海马在应激过程中对丘脑-垂体-肾上腺皮质（HPA）轴反馈调节作用的当前进展。研究表明，应激可影响海马的结构和功能，另一方面，海马也可通过HPA轴的反馈调节抑制应激反应，但慢性应激会削弱这种调节作用，进而显著损害其结构和功能。