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手性毛细管电泳和毛细管电色谱的药物及生物医学应用:最新进展

Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: an update.

作者信息

Scriba Gerhard K E

机构信息

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Jena, Philosophenweg 14, D-07743 Jena, Germany.

出版信息

Electrophoresis. 2003 Aug;24(15):2409-21. doi: 10.1002/elps.200305491.

Abstract

Capillary electrophoresis is often considered an ideal method for the chiral analysis of compounds due to the high separation power of the technique and has therefore found widespread acceptance for the analysis of drugs and pharmaceuticals. In contrast, capillary electrochromatography is still more or less in an infancy state searching for its place among the analytical separation techniques although interesting applications have been published. The present review summarizes recent developments and applications of chiral pharmaceutical analysis by electromigration techniques published in 2002 and early 2003.

摘要

由于毛细管电泳技术具有高分离能力,它常被认为是化合物手性分析的理想方法,因此在药物分析中得到了广泛应用。相比之下,毛细管电色谱仍处于发展初期,尽管已有一些有趣的应用报道,但仍在寻找其在分析分离技术中的定位。本综述总结了2002年及2003年初发表的有关手性药物分析电迁移技术的最新进展和应用。

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