ELBERG S S, SCHNEIDER P, FONG J
J Exp Med. 1957 Oct 1;106(4):545-54. doi: 10.1084/jem.106.4.545.
A non-specific element has been demonstrated in the resistance of monocytes derived from immunized rabbits. Vaccination by BCG or by an effective anti-brucellosis reagent induces protection in either case against both Mycobacterium tuberculosis and Brucella melitensis when studied by the monocyte culture method. The activity of the antiserum required to demonstrate the resistance of the monocyte is not affected when the agglutinating action of the anti-Brucella rabbit serum is removed by absorption. The ability of the monocytes from specifically immunized rabbits to retard the growth of virulent Brucella was demonstrated, not as an all-or-none phenomenon, but in the light of the unrestricted bacterial multiplication which occurs in monocytes from normal animals.
在免疫兔来源的单核细胞的抗性中已证实存在一种非特异性成分。当通过单核细胞培养方法进行研究时,用卡介苗或有效的抗布鲁氏菌病试剂进行接种,在这两种情况下均可诱导对结核分枝杆菌和羊布鲁氏菌的保护作用。当通过吸收去除抗布鲁氏菌兔血清的凝集作用时,证明单核细胞抗性所需的抗血清活性不受影响。已证明,来自特异性免疫兔的单核细胞抑制强毒布鲁氏菌生长的能力并非全或无现象,而是相对于正常动物单核细胞中发生的不受限制的细菌繁殖而言的。