高密度脂蛋白的促炎/抗炎特性比高密度脂蛋白胆固醇水平能更好地区分患者与对照受试者，且辛伐他汀治疗对其有积极影响。

Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment.

作者信息

Ansell Benjamin J, Navab Mohamad, Hama Susan, Kamranpour Naeimeh, Fonarow Gregg, Hough Greg, Rahmani Shirin, Mottahedeh Rachel, Dave Ravi, Reddy Srinivasa T, Fogelman Alan M

机构信息

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095-1679, USA.

出版信息

Circulation. 2003 Dec 2;108(22):2751-6. doi: 10.1161/01.CIR.0000103624.14436.4B. Epub 2003 Nov 24.

DOI:10.1161/01.CIR.0000103624.14436.4B

PMID:14638544

Abstract

BACKGROUND

The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects.

METHODS AND RESULTS

Group 1 consisted of 26 patients not yet taking a statin who presented with coronary heart disease (CHD) or CHD equivalents by National Cholesterol Education Program Adult Treatment Panel III criteria studied before and 6 weeks after 40 mg/d of simvastatin. Group 2 consisted of 20 patients with documented CHD and HDL cholesterol > or =84 mg/dL. The inflammatory/antiinflammatory properties of HDL were determined by the ability of the subject's HDL to alter LDL-induced monocyte chemotactic activity (MCA) in a human artery wall coculture. Induction of MCA by a control LDL was determined in the absence or presence of the subject's HDL. Values in the absence of HDL were normalized to 1.0. Values >1.0 after the addition of HDL indicated proinflammatory HDL; values <1.0 indicated antiinflammatory HDL. Group 1 values before simvastatin were LDL cholesterol, 118+/-24 mg/dL; HDL cholesterol, 57+/-13 mg/dL; triglycerides, 125+/-64 mg/dL; and high-sensitivity C-reactive protein (hs-CRP), 1.7+/-1.9 mg/L; and MCA values were 1.38+/-0.91, compared with 0.38+/-0.14 for control subjects (P=1.5x10(-5)). After simvastatin, values were LDL cholesterol, 73+/-24 mg/dL; HDL cholesterol, 61+/-14 mg/dL; triglycerides, 99+/-52 mg/dL; and hs-CRP, 1.3+/-1.3 mg/L; and MCA values were 1.08+/-0.71. In group 2, values were LDL cholesterol, 108+/-34 mg/dL; HDL cholesterol, 95+/-14 mg/dL; triglycerides, 89+/-44 mg/dL; and hs-CRP, 0.8+/-0.7 mg/L; and MCA values were 1.28+/-0.29, compared with 0.35+/-0.11 for control subjects (P=1.7x10(-14)). Similar results were obtained with the cell-free assay.

CONCLUSIONS

The inflammatory/antiinflammatory properties of HDL distinguished patients from control subjects better than HDL cholesterol and were improved with simvastatin.

摘要

背景

在两组患者以及年龄和性别匹配的对照受试者中，对高密度脂蛋白（HDL）的促炎/抗炎特性与HDL胆固醇进行了比较。

方法与结果

第1组由26例尚未服用他汀类药物的患者组成，这些患者根据美国国家胆固醇教育计划成人治疗小组III标准，表现为冠心病（CHD）或CHD等效病症，在服用40mg/d辛伐他汀之前和之后6周进行了研究。第2组由20例确诊为CHD且HDL胆固醇≥84mg/dL的患者组成。HDL的促炎/抗炎特性通过受试者的HDL改变人动脉壁共培养中低密度脂蛋白（LDL）诱导的单核细胞趋化活性（MCA）的能力来确定。在不存在或存在受试者HDL的情况下，测定对照LDL诱导的MCA。不存在HDL时的值标准化为1.0。添加HDL后值>1.0表明HDL具有促炎作用；值<1.0表明HDL具有抗炎作用。第1组在服用辛伐他汀之前，LDL胆固醇值为118±24mg/dL；HDL胆固醇值为57±13mg/dL；甘油三酯值为125±64mg/dL；高敏C反应蛋白（hs-CRP）值为1.7±1.9mg/L；MCA值为1.38±0.（此处原文有误，应为0.91），而对照受试者的MCA值为0.38±0.14（P = 1.5×10⁻⁵）。服用辛伐他汀后，LDL胆固醇值为73±24mg/dL；HDL胆固醇值为61±14mg/dL；甘油三酯值为99±52mg/dL；hs-CRP值为1.3±1.3mg/L；MCA值为1.08±0.71。在第2组中，LDL胆固醇值为108±34mg/dL；HDL胆固醇值为95±14mg/dL；甘油三酯值为89±44mg/dL；hs-CRP值为0.8±0.7mg/L；MCA值为1.28±0.29，而对照受试者的MCA值为0.35±0.11（P = 1.7×10⁻¹⁴）。无细胞试验也得到了类似结果。（此处原文有误，应为Similar results were obtained with the cell-free assay.）