FoxO穿梭的来龙去脉：FoxO易位及转录调控机制
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
作者信息
Van Der Heide Lars P, Hoekman Marco F M, Smidt Marten P
机构信息
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
出版信息
Biochem J. 2004 Jun 1;380(Pt 2):297-309. doi: 10.1042/BJ20040167.
Abstract
FoxO (forkhead box O; forkhead members of the O class) are transcription factors that function under the control of insulin/insulin-like signalling. FoxO factors have been associated with a multitude of biological processes, including cell-cycle, cell death, DNA repair, metabolism and protection from oxidative stress. Central to the regulation of FoxO factors is a shuttling system, which confines FoxO factors to either the nucleus or the cytosol. Shuttling of FoxO requires protein phosphorylation within several domains, and association with 14-3-3 proteins and the nuclear transport machinery. Description of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation.
摘要
FoxO（叉头框O；O类叉头成员）是在胰岛素/胰岛素样信号传导控制下发挥作用的转录因子。FoxO因子与多种生物学过程相关，包括细胞周期、细胞死亡、DNA修复、新陈代谢以及抗氧化应激保护。FoxO因子调节的核心是一种穿梭系统，该系统将FoxO因子限制在细胞核或细胞质中。FoxO的穿梭需要几个结构域内的蛋白质磷酸化，以及与14-3-3蛋白和核转运机制的结合。对FoxO穿梭机制的描述有助于理解FoxO在信号传导和基因调控方面的功能。
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