Kenseth Jeremy R, He Yan, Tallman Dennis, Pang Ho-ming, Coldiron Shelley J
CombiSep, Inc., 2711 South Loop Drive, Ames, Iowa 50010, USA.
Curr Opin Chem Biol. 2004 Jun;8(3):327-33. doi: 10.1016/j.cbpa.2004.03.001.
Combinatorial processes have been widely applied to many disciplines in chemistry and biology. The vast numbers of unique entities generated by combinatorial synthesis have led to the development of high-throughput methods for characterizing samples, to avoid bottlenecks created by the application of conventional, serial-based analytical techniques. In recent years, high-throughput and novel methods utilizing mass spectrometry, multiplexed capillary electrophoresis, various forms of optical detection, and even sound waves have been investigated for a variety of applications.
组合方法已广泛应用于化学和生物学的许多学科。组合合成产生的大量独特实体推动了用于表征样品的高通量方法的发展,以避免传统的基于序列的分析技术应用所造成的瓶颈。近年来,人们研究了利用质谱、多重毛细管电泳、各种形式的光学检测甚至声波的高通量和新颖方法,以用于各种应用。